The Machame Route has a very good altitude profile of hiking high and sleeping low. This allows for proper altitude acclimatization and decreases the risk of getting acute mountain sickness. It also increases the summit success chance.
Furthermore, the Machame Route doesn’t include the dangerous Western Breach, which we recommend avoiding at all times.
However, the steep Barranco Wall is included in this route. If you suffer from serious vertigo, you might prefer to avoid this challenging climb.